“The definition of an inactive subscriber will be unique to every business, but ultimately you need to be able to define an inactive subscriber as someone who hasn’t opened/clicked within a certain amount of time. Once you’ve established your definition of inactivity, segment the subscribers who fit into a group that will receive a workflow of re-engagement emails.”
Some subscribers will need more attention than others. First, define who/what constitutes an inactive subscriber, then segment those individuals into a separate list and hatch a plan to reengage these people with a series of emails designed to ignite engagement and possibly a sale.